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How LDN works

Low Dose Naltrexone, or LDN, I a non-toxic drug that helps to reduce pain and inflammation and is typically used to treat a wide range of diseases, including cancer, chronic pain, and autoimmune issues.

LDN is administered externally and works by binding to the body’s natural opioid receptors. In the process of doing this, it displaces the endorphins already attached. LDN only binds to these receptors for a short time, encouraging the production and sensitivity of the receptors, which in turn increases OGF production.

As your body metabolizes the LDN, the new endorphins produced during the rebound effect are able to interact and engage with your body’s receptors, helping to regulate the growth and immunity of your cells. Many people wonder what the Low Dose Naltrexone adverse effects might be, but LDN is a pure inhibitor, which means it has no narcotic effects on the patient.

  • Alongside being a pure inhibitor, Low Dose Naltrexone is also incredibly safe, and most patients will not experience any severe side effects while using it. However, on occasion, there can be some minor side effects.

    For those using it to treat MS, they might notice that certain symptoms can become worse, such as increased fatigue or spasticity. Patients might also see an onset of symptoms similar to the flu, while if taken later in the evening, then they might additionally experience mild sleep disturbance due to the increase of endorphins. These disturbances could be having difficulty falling asleep or having highly vivid dreams.Experience has shown that in less than 10% of cases, introductory symptoms can be more severe or prolonged and last several weeks, and it is very rare for symptoms to last longer than three months. If side effects are bothering you, then reducing your dosage by 50% for seven days can alleviate this.Very rarely, patients might experience gastrointestinal issues such as diarrhea and nausea. In this instance, LDN Sublingual Drops can be used to provide Low Dose Naltrexone directly to the bloodstream, bypassing the GI tract.Conditions to be treatedLow Dose Naltrexone can be used to treat a wide range of diseases and illnesses. The treatment is designed to reduce pain, inflammation, autoimmune diseases, and fatigue. This means it is suitable for some of the most common issues in the world.This includes cardiac diseases such as Kawasaki’s disease and Subacute Bacterial Endocarditis (SB), endocrine diseases such as Addison’s and Hypoglycaemia, Gastrointestinal issues such as Celiac disease and Chron’s disease, and a range of pulmonary, renal, and urologic conditions.Low Dose Naltrexone indications have shown that it can also be successfully used to reduce conditions most commonly associated with Ears, Nose, Sinus, and Throat issues, Dermatological issues, Ocular issues, Paediatric disorders, and Vasculitis.Alongside health issues, taking Low Dose Naltrexone can also be used in treating some of the most common problems experienced today, including sleep disorders, depression, anxiety, and stress. Women can also use it to help relieve pain and discomfort from pregnancy and premenstrual syndrome (PMS).Dosages LDN is compounded for use across the United States in various forms and comes in a range of delivery options such as capsules, liquids, and creams. Low Dose Naltrexone dosage will depend on the conditions being treated and the individual sensitivity of each patient.Typically, Low Dose Naltrexone dosage can be classified into one of five categories:
    • Ultra-low
    This is a microgram dosing that is administered twice a day
    • Very Low Dose
    This category is used for daily doses that are between 0.1 and 0.5mg
    • Low Dose
    This category refers to doses that are under 4.5mg
    • Moderate Dose
    A moderate dose is for those doses less than 25mg
    • High Dose
    This category refers to daily amounts over 50mg.Types of LDNLow Dose Naltrexone can be administered at home and is available in a wide range of solutions, including:LiquidThis is the most common and affordable method of application and is typically available in 1mg/1ml doses.CapsulesCapsules are available in a range of strengths, but you should utilize a trusted compounding pharmacy to ensure you are always getting the highest quality solutions.Sublingual DropsFor those patients who have issues with taking medications orally, then LDN is also available as a sublingual drop. This method sees users place a few drops of the solution under their tongue using a dropper and allows them to increase or decrease their dosage as required. Sublingual drops are also one of the fastest-acting methods of taking LDN.Cream and LotionLDN cream and lotions typically come in a Very Low Dose classification, and they work by direct application to the skin. This makes them a more suitable solution for children or people uncomfortable with oral applications.Eye DropsLow Dose Naltrexone can also be used to treat dry eyes, which is why Low Dose Naltrexone is also available in a low dose eye drop, allowing patients to administer it directly.Tablets Another very common form of administering LDN is in tablet form, which is available in a range of strengths from various compounding pharmacies across the country.LDN resourcesIf you are looking to find out more information about Low Dose Naltrexone, there are a range of resources available, including the LDN Research Trust.For more information on dosage and administering, visit the LDN 2020 Dosing Information.For more information on LDN and its use, you can learn more about it with the LDN 2020 Patient Information Packet and the LDN Prescriber Information.

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